Selected Publications (* equal contributions)
2024
Sun X, Wu C, Lu B, Ballon C, Hwangbo Y, Johnson D, Liang H, Shrestha P, Mills AA. CHD5 governs MYC expression through chromatin remodeling to inhibit gliomagenesis. (First author, paper in preparation).
Liang H, Fisher ML, Wu C, Ballon C, Sun X, Mills A A. PRMT5/WDR77 Enhances the Proliferation of Squamous Cell Carcinoma via the ΔNp63α-p21 Axis. Cancers (Basel) 2024 Nov 11;16(22):3789. doi: 10.3390/cancers16223789.
2023
Sun X, Klingbeil O, Lu B, Wu C, Ballon C, Ouyang M, Wu XS, Jin Y, Hwangbo Y, Huang YH, Somerville TDD, Chang K, Park J, Chung T, Lyons SK, Shi J, Vogel H, Schulder M, Vakoc CR, Mills AA. BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network. Nature. 2023;613(7942):195-202. Epub 2022/12/22. doi: 10.1038/s41586-022-05551-x. PubMed PMID: 36544023.
Featured by ABC news (https://abc7ny.com/glioblastoma-brain-cancer-cold-spring-harbor-lab-long-island/12759592/), TBR news ( https://tbrnewsmedia.com/cshls-alea-mills-xueqin-sun-discover-new-possible-vulnerability-in-brain-cancer/), and China Science Daily (https://news.sciencenet.cn/htmlnews/2023/2/493968.shtm), etc.
2022
Balinth S, Fisher ML, Hwangbo Y, Wu C, Ballon C, Sun X, Mills AA. EZH2 regulates a SETDB1/DeltaNp63alpha axis via RUNX3 to drive a cancer stem cell phenotype in squamous cell carcinoma. Oncogene. 2022. Epub 2022/07/22. doi: 10.1038/s41388-022-02417-4. PubMed PMID: 35864175.
2020—
Yang X*, Lu B*, Sun X*, Han C, Fu C, Xu K, Wang M, Li D, Chen Z, Opal P, Wen Q, Crispino JD, Wang QF, Huang Z. ANP32A regulates histone H3 acetylation and promotes leukemogenesis. Leukemia. 2018;32(7):1587-97. Epub 2018/02/23. doi: 10.1038/s41375-018-0010-7. PubMed PMID: 29467488.
Sun X*, Lu B*, Han C*, Qiu W, Jin Q, Li D, Li Q, Yang Q, Wen Q, Opal P, Kini AR, Crispino JD, Huang Z. ANP32A dysregulation contributes to abnormal megakaryopoiesis in acute megakaryoblastic leukemia. Blood Cancer J. 2017;7(12):661. Epub 2017/12/23. doi: 10.1038/s41408-017-0031-x. PubMed PMID: 29269781; PMCID: PMC5802576.
Lu B*, Ren Y*, Sun X*, Han C, Wang H, Chen Y, Peng Q, Cheng Y, Cheng X, Zhu Q, Li W, Li HL, Du HN, Zhong B, Huang Z. Induction of INKIT by Viral Infection Negatively Regulates Antiviral Responses through Inhibiting Phosphorylation of p65 and IRF3. Cell Host & Microbe. Cover story. 2017;22(1):86-98 e4. Epub 2017/07/14. doi: 10.1016/j.chom.2017.06.013. PubMed PMID: 28704656.
Lu B*, Sun X*, Chen Y, Jin Q, Liang Q, Liu S, Li Y, Zhou Y, Li W, Huang Z. Novel function of PITH domain-containing 1 as an activator of internal ribosomal entry site to enhance RUNX1 expression and promote megakaryocyte differentiation. Cell Mol Life Sci. 2015;72(4):821-32. Epub 2014/08/20. doi: 10.1007/s00018-014-1704-2. PubMed PMID: 25134913.
Sun X*, Lu B*, Hu B, Xiao W, Li W, Huang Z. Novel function of the chromosome 7 open reading frame 41 gene to promote leukemic megakaryocyte differentiation by modulating TPA-induced signaling. Blood Cancer J. 2014;4:e198. Epub 2014/04/01. doi: 10.1038/bcj.2014.18. PubMed PMID: 24681962; PMCID: PMC3972703.
Book Chapter
2023
Sun X*, Shrestha P*, and Mills AA. CHROMO Readers: a Rainbow of Opportunities. Chromatin Readers in Health and Disease – Translational Epigenetics Series Textbook (Elsevier/Academic Press – ISBN 9780128233764, 2023).