The successful treatment of diseases, including cancer, depends on a deep understanding of the molecular mechanisms involved. Cancer is primarily caused by aberrant gene expression, which occurs due to misinterpretations of genetic and epigenetic information. Our research aims to uncover the DNA-related alterations driving cancer-specific transcriptional programs, with the ultimate goal of identifying vulnerabilities unique to cancer cells. By understanding these mechanisms, we hope to develop targeted therapies that more precisely treat cancer, improving patient outcomes and reducing side effects by focusing on the root causes of tumorigenesis.